Ziwig Endotest
What is Ziwig Endotest® ?
- It is an in vitro diagnostic device for use by healthcare professionals for the diagnosis of endometriosis from a saliva sample.
- It is an innovative, non invasive, diagnostic tool based on the analysis of salivary miRNAs via NGS (Next Generation Sequencing) and by AI (Artificial Intelligence).
- It exceeds the performance of conventional diagnostic tests1-5 (sensitivity >97%, specificity >93%6).
- Sensitivity of 97%
- Specificity of 95%
- Diagnostic accuracy (AUC) of 96%*
What is endometriosis?
Main symptoms of endometriosis
- Severe pelvic pain
- Menstrual pain
- Pain during sexual intercourse
- Pelvic pain outside of menstruation
- Pain in the right shoulder
- Digestive problems
- Intense fatigue
- Urinary disorders
- Infertility
- Pain during defecation
- Alternating diarrhea - constipation
- Lower back pain
Advantages of Ziwig Endotest
Clear positive/ negative result
Rapid diagnosis
All forms and stages of endometriosis can be diagnosed$/n
High reliability: (sensitivity> 97%, specificity >93%)ª
Simple and non-invasive saliva sample
The Ziwig Endotest® offers a groundbreaking, non-invasive, and highly accurate (96%) saliva-based diagnostic method for endometriosis, enabling early detection, reducing diagnostic delays, and improving patient care and treatment outcomes.
The science behind Ziwig Endotest: Micro-RNAs
- What Are microRNAs (miRNAs)? Small molecules that regulate gene expression and play a key role in various diseases, including endometriosis.
- Non-Invasive Saliva-Based Test: Utilizes a simple saliva sample, offering a comfortable and non-invasive diagnostic option.
- Advanced Technology: Combines Next-Generation Sequencing (NGS) and Artificial Intelligence (AI) to analyze complex miRNA data.
- High Accuracy and Reliable Results: Detects a specific panel of 109 microRNAs with 95% accuracy, providing clear positive or negative outcomes for early and accurate endometriosis diagnosis.
The workflow
From prescription to providing results
Requested by a healthcare professional
Sample collection
Shipment of sample
Central laboratory analysis
Receipt of results
- Early and reliable diagnosis of endometriosis.
- Intended for patients aged between 18 and 43 years.
- For patients with symptoms suggestive of endometriosis.
- Ziwig work has been published in several scientific peer-reviewed journals.
The Ziwig Endotest is backed by extensive research and proven through studies. This innovative test offers a reliable, non-invasive solution for diagnosing endometriosis, providing accurate results and helping improve patient care.
The studies on Ziwig Endotest® have been published in international peer-reviewed scientific journals.
Find all the publications and their abstracts on the website www.ziwig.com www.ziwig.com
June 2023
Validation of the Salivary miRNA Signature of Endometriosis — Interim Data
May 2023
Value of non-coding RNAs to assess lymph node status in cervical cance
November 2022
Saliva microRNA signature to diagnose endometriosis: A cost-effectiveness evaluation of the Endotest®
October 2022
Endometriosis-associated infertility diagnosis based on saliva microRNA signatures
July 2022
A Bioinformatics Approach to MicroRNA-Sequencing Analysis Based on Human Saliva Samples of Patients with Endometriosis
May 2022
Endometriosis Associated-miRNome Analysis of Blood Samples: A Prospective Study
March 2022
MicroRNome analysis generates a blood-based signature for endometriosis
January 2022
Salivary MicroRNA Signature for Diagnosis of Endometriosis
January 2022
Clues for Improving the Pathophysiology Knowledge for Endometriosis Using Serum Micro-RNA Expression
January 2022
Machine learning algorithms as new screening approach for patients with endometriosis
All you need to know about the process
Yes, the Ziwig Endotest® is completely non-invasive. It only requires a simple saliva sample, avoiding the need for any surgical or uncomfortable procedures.
The Ziwig Endotest® offers exceptional accuracy in detecting endometriosis, with a sensitivity of 97%, a specificity of 95%, and a diagnostic accuracy (AUC) of 96%. This non-invasive test provides reliable results using advanced artificial intelligence and next-generation sequencing
The Ziwig Endotest® is a simple and non-invasive test that involves collecting a saliva sample. To do this, gently spit into the sample tube through the provided funnel until the liquid (without air bubbles) reaches or slightly exceeds the fill line.
Once the sample is ready, your doctor will securely seal the tube and arrange for its safe shipment to the laboratory.
Your doctor is there to guide you every step of the way. If you have any questions or need support, don't hesitate to reach out!
The sampling process for the Ziwig Endotest® is quick and easy. It typically takes just a few minutes to collect the saliva sample. Simply spit into the provided funnel, seal the tube, and you're done!
Yes, please observe the following instructions 30 minutes before sampling:
Wash your hands thoroughly.
Do not use the test if you are unwell (e.g., have an infection).
Do not eat or drink.
Do not smoke.
Do not chew gum.
Do not wear lipstick.
Do not brush your teeth.
These measures help ensure that the test results are as accurate as possible. It's important that the saliva is clear and free of food residue or blood.
he Ziwig Endotest® is specifically designed for patients between 18 and 43 years old who exhibit symptoms suggestive of possible endometriosis and in whom ultrasound does not provide clear evidence of endometriosis. The Ziwig Endotest® offers a faster and more efficient alternative to laparoscopy or imaging procedures for diagnosis.
It is crucial to address any uncertainty about the possibility of endometriosis as early as possible. Therefore, if you experience symptoms such as severe menstrual pain, pain during intercourse, or fertility problems, the Ziwig Endotest® could be a meaningful diagnostic option.
You or your clinic will ship the sample to PWCRI’s headquarters in Mumbai. There, it undergoes quality checks before being sent to Ziwig’s specialized lab overseas for in-depth analysis.
The entire process takes about one month from the time you collect your sample. This includes shipping, analysis, and verification. Your doctor will inform you once the results are ready.
Once Precision Women's Care and Research Institute (PWCRI) receives the test results, we will email the patient or their consultant doctor with a clear "yes" or "no" result.
If you receive a positive result from the Ziwig Endotest®, it's important to book an appointment with a gynecologist or an endometriosis specialist to discuss the next steps.